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Open Source Antibiotics / Series 1 - the Mur Ligases

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Open Source Antibiotics / Series 1 - the Mur Ligases

These are all the meetings we have in "Series 1 - the Mur L…" (part of the organization "Open Source Antibiotics"). Click into individual meeting pages to watch the recording and search or read the transcript.

12 Sep 2023
Open project meeting for Open Source Antibiotics Series 1, the Mur Ligases.

Full Project: https://github.com/opensourceantibiot...

Relevant GitHub Issue: https://github.com/opensourceantibiotics/murligase/issues/102

On the call: Prof. Matthew Todd, Yuhang Wang, Yiwei Wang (UCL), Prof Chris Dowson (chair), Dr Adrian Lloyd and Dr Laura Diaz Saez (University of Warwick), Dr Joe Eyermann, Dr Lori Ferrins (Northeastern University), Bart Staker (SSGCID), Jan Abendroth (UCB Pharma).
  • 6 participants
  • 32 minutes
compounds
assays
reaction
atomized
screening
labs
triage
contributions
preliminary
concerned
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8 Aug 2023
Open project meeting for Open Source Antibiotics Series 1, the Mur Ligases.

Full Project: https://github.com/opensourceantibiot...

Relevant GitHub Issue: https://github.com/opensourceantibiotics/murligase/issues/101

On the call: Prof. Matthew Todd, Yuhang Wang, Yiwei Wang (UCL), Prof Chris Dowson (chair), Dr Adrian Lloyd and Dr Laura Diaz Saez (University of Warwick), Dr Joe Eyermann, Dr Lori Ferrins (Northeastern University), Bart Staker (SSGCID), Jan Abendroth (UCB Pharma).
  • 7 participants
  • 31 minutes
antibiotics
crystals
enamine
incubator
experiments
discussed
ic50s
hopefully
adrian
purification
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11 Jul 2023
Open project meeting for Open Source Antibiotics Series 1, the Mur Ligases.

Full Project: https://github.com/opensourceantibiot...

Relevant GitHub Issue: https://github.com/opensourceantibiotics/murligase/issues/100

On the call: Prof. Matthew Todd, Yuhang Wang, Yiwei Wang (UCL), Prof Chris Dowson (chair), Dr Adrian Lloyd and Dr Laura Diaz Saez (University of Warwick), Dr Joe Eyermann, Dr Lori Ferrins (Northeastern University), Bart Staker (SSGCID), Jan Abendroth (UCB Pharma).
  • 5 participants
  • 30 minutes
antibiotics
inhibitors
enamine
ic50
chemotype
millimolent
concentrations
assays
heterocyclic
concerned
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13 Jun 2023
Open project meeting for Open Source Antibiotics Series 1, the Mur Ligases.

Full Project: https://github.com/opensourceantibiot...

Relevant GitHub Issue: https://github.com/opensourceantibiotics/murligase/issues/99

On the call: Prof. Matthew Todd, Yuhang Wang, Yiwei Wang (UCL), Prof Chris Dowson (chair), Dr Adrian Lloyd and Dr Laura Diaz Saez (University of Warwick), Dr Joe Eyermann, Dr Lori Ferrins (Northeastern University), Bart Staker (SSGCID), Jan Abendroth (UCB Pharma).
  • 8 participants
  • 53 minutes
antibiotics
enzyme
contamination
issue
inhibitor
updated
effectively
screening
suspected
microphone
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9 May 2023
Open project meeting for Open Source Antibiotics Series 1, the Mur Ligases.

Full Project: https://github.com/opensourceantibiot...

Relevant GitHub Issue: https://github.com/opensourceantibiotics/murligase/issues/97

On the call: Dr Edwin Tse, Yuhang Wang, Yiwei Wang (UCL), Prof Chris Dowson (chair), Dr Adrian Lloyd and Dr Laura Diaz Saez (University of Warwick), Dr Joe Eyermann, Dr Lori Ferrins (Northeastern University), Bart Staker (SSGCID), Jan Abendroth (UCB Pharma).
  • 8 participants
  • 50 minutes
issue
discussed
meet
antibiotics
conclusions
interactions
wyh9
takes
compound
ic50
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14 Mar 2023
Open project meeting for Open Source Antibiotics Series 1, the Mur Ligases.

Full Project: https://github.com/opensourceantibiot...

Relevant GitHub Issue: https://github.com/opensourceantibiotics/murligase/issues/95

On the call: Dr Edwin Tse, Yuhang Wang, Yiwei Wang (UCL), Prof Chris Dowson (chair), Dr Adrian Lloyd and Dr Laura Diaz Saez (University of Warwick), Dr Joe Eyermann, Dr Lori Ferrins (Northeastern University), Bart Staker (SSGCID), Jan Abendroth (UCB Pharma).
  • 7 participants
  • 21 minutes
enamine
crystals
compounds
chemistry
phosphate
ado6
issue
awaiting
things
repurifying
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14 Feb 2023
Open project meeting for Open Source Antibiotics Series 1, the Mur Ligases.

Full Project: https://github.com/opensourceantibiotics/murligase

Relevant GitHub Issue: https://github.com/opensourceantibiotics/murligase/issues/94

On the call: Dr Edwin Tse, Yuhang Wang, Yiwei Wang (UCL), Prof Chris Dowson (chair), Dr Adrian Lloyd and Dr Laura Diaz Saez (University of Warwick), Dr Joe Eyermann, Dr Lori Ferrins (Northeastern University), Bart Staker (SSGCID), Jan Abendroth (UCB Pharma).
  • 9 participants
  • 39 minutes
antibiotics
concern
dmso
provided
compounds
enzymology
inhibitors
updates
merlog
milligrams
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13 Dec 2022
Open project meeting for Open Source Antibiotics Series 1, the Mur Ligases.

Full Project: https://github.com/opensourceantibiotics/murligase

Relevant GitHub Issue: https://github.com/opensourceantibiotics/murligase/issues/92

On the call: Dr Edwin Tse, Yuhang Wang, Yiwei Wang (UCL), Prof Chris Dowson (chair), Dr Adrian Lloyd and Dr Laura Diaz Saez (University of Warwick), Dr Joe Eyermann, Dr Lori Ferrins (Northeastern University), Bart Staker (SSGCID), Jan Abendroth (UCB Pharma).
  • 7 participants
  • 51 minutes
crystals
crystal
crystallography
crystallization
diamond
diffraction
experiments
damaged
issue
retrospectively
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8 Nov 2022
Open project meeting for Open Source Antibiotics Series 1, the Mur Ligases.
Full Project: https://github.com/opensourceantibiotics/murligase
Relevant GitHub Issue: https://github.com/opensourceantibiotics/murligase/issues/91
On the call: Dr Edwin Tse, Yuhang Wang, Yiwei Wang (UCL), Prof Chris Dowson (chair), Dr Adrian Lloyd and Dr Laura Diaz Saez (University of Warwick), Dr Joe Eyermann, Dr Lori Ferrins (Northeastern University) (?), Bart Staker (SSGCID), Jan Abendroth (UCB Pharma).
  • 11 participants
  • 1:02 hours
antibiotics
purification
enzyme
contamination
phosphate
problems
pseudomonas
reagent
assay
reaction
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11 Oct 2022
Open project meeting for Open Source Antibiotics Series 1, the Mur Ligases.
Full Project: https://github.com/opensourceantibiotics/murligase
Relevant GitHub Issue: https://github.com/opensourceantibiotics/murligase/issues/90
On the call: Professor Matthew Todd, Dr Edwin Tse, Yuhang Wang, Dr Daniel Gedder, Andy Kim (UCL), Dr Adrian Lloyd and Dr Laura Diaz Saez (University of Warwick), Dr Joe Eyermann, Dr Lori Ferrins (Northeastern University).
  • 5 participants
  • 38 minutes
discussed
crystals
having
structure
concerns
closer
hints
2022
lcms
uk
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13 Sep 2022
Open project meeting for Open Source Antibiotics Series 1, the Mur Ligases.
Full Project: https://github.com/opensourceantibiotics/murligase
Relevant GitHub Issue: https://github.com/opensourceantibiotics/murligase/issues/88
On the call: Professor Matthew Todd, Dr Edwin Tse, Yuhang Wang, Dr Daniel Gedder (UCL), Dr Adrian Lloyd and Dr Laura Diaz Saez (University of Warwick), Dr Joe Eyermann (Northeastern University), Dr Chris Swain (Cambridge MedChem Consulting), Dr Jan Abendroth (UCB Biosciences), Dr Bart Staker (SSGCID), Prof Jan Jensen (Uni Copenhagen), Roman (observer, not sure of institution).
  • 9 participants
  • 49 minutes
antibiotics
process
enzymes
pseudomonas
lab
examined
purification
samples
prescribed
mer
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9 Aug 2022
Open project meeting for Open Source Antibiotics Series 1, the Mur Ligases.
Full Project: https://github.com/opensourceantibiotics/murligase
Relevant GitHub Issue: https://github.com/opensourceantibiotics/murligase/issues/87
On the call: Professor Matthew Todd, Dr Edwin Tse, Yuhang Wang, Dr Daniel Gedder (UCL), Dr Laura Diaz Saez (University of Warwick), Dr Joe Eyermann (Northeastern University), Dr Chris Swain (Cambridge MedChem Consulting), Dr Jan Abendroth (UCB Biosciences), Dr Bart Staker (SSGCID).
  • 8 participants
  • 50 minutes
antibiotics
research
microbiology
lifehack
updated
ago
discussion
bacteria
antibacterials
retesting
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12 Jul 2022
Open project meeting for Open Source Antibiotics Series 1, the Mur Ligases.
Full Project: https://github.com/opensourceantibiotics/murligase
Relevant GitHub Issue: https://github.com/opensourceantibiotics/murligase/issues/86
On the call: Professor Matthew Todd, Dr Edwin Tse, Yuhang Wang, Kato Leonard (UCL), Professor Chris Dowson, Laura Diaz Saez, Adrian Lloyd (University of Warwick), Lizbe Koekemoer (Diamond/Oxford), Dr Lori Ferrins, Dr Joe Eyermann (Northeastern University), Dr Chris Swain (Cambridge MedChem Consulting), Dr Jan Abendroth (UCB Biosciences), Dr Bart Staker (SSGCID).
  • 8 participants
  • 38 minutes
amino
mudadp
advances
addressing
antibiotics
prepared
crystals
experiments
precipitating
assay
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14 Jun 2022
Open project meeting for Open Source Antibiotics Series 1, the Mur Ligases.
Full Project: https://github.com/opensourceantibiotics/murligase
Relevant GitHub Issue: https://github.com/opensourceantibiotics/murligase/issues/76
On the call: Professor Matthew Todd, Dr Edwin Tse, Yuhang Wang, Kato Leonard (UCL), Professor Chris Dowson, Laura Diaz Saez, Adrian Lloyd (University of Warwick), Lizbe Koekemoer (Diamond/Oxford), Dr Lori Ferrins, Dr Joe Eyermann (Northeastern University), Dr Chris Swain (Cambridge MedChem Consulting), Dr Jan Abendroth (UCB Biosciences), Dr Bart Staker (SSGCID).
  • 9 participants
  • 57 minutes
discussions
alien
appear
investigating
having
suggesting
warwick
025
currently
adrian
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8 Jun 2022
Open project meeting for Open Source Antibiotics Series 1, the Mur Ligases.
Full Project: https://github.com/opensourceantibiotics/murligase
Relevant GitHub Issue: https://github.com/opensourceantibiotics/murligase/issues/80
One-off meeting focussing on current status of crystallography in the project
On the call: Professor Matthew Todd, Yuhang Wang (UCL), Professor Chris Dowson, Laura Diaz Saez (University of Warwick), Lizbe Koekemoer (Diamond/Oxford), Dr Lori Ferrins, Dr Joe Eyermann (Northeastern University), Dr Jan Abendroth (UCB Biosciences), Dr Bart Staker (SSGCID).
  • 6 participants
  • 53 minutes
subunits
project
organisms
crystallize
summary
sequencing
sections
amino
structure
molecule
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10 May 2022
Open project meeting for Open Source Antibiotics Series 1, the Mur Ligases.
Full Project: https://github.com/opensourceantibiotics/murligase
Relevant GitHub Issue: https://github.com/opensourceantibiotics/murligase/issues/75
On the call: Professor Matthew Todd, Dr Edwin Tse, Yuhang Wang, Kato Leonard (UCL), Professor Chris Dowson, Laura Diaz Saez, Adrian Lloyd (University of Warwick), Lizbe Koekemoer (Diamond/Oxford), Dr Lori Ferrins, Dr Joe Eyermann (Northeastern University), Dr Chris Swain (Cambridge MedChem Consulting), Dr Jan Abendroth (UCB Biosciences), Dr Bart Staker (SSGCID).
  • 14 participants
  • 42 minutes
ongoing
antibiotics
thanks
2022
conference
expecting
hopefully
batch
project
monitoring
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12 Apr 2022
Open project meeting for Open Source Antibiotics Series 1, the Mur Ligases.
Full Project: https://github.com/opensourceantibiotics/murligase
Relevant GitHub Issue: https://github.com/opensourceantibiotics/murligase/issues/71
On the call: Prof Chris Dowson, Dr Adrian Lloyd, Laura Diaz Saez (University of Warwick), Dr Edwin Tse, Yuhang Wang, Kato Leonard (UCL), Lizbe Koekemoer (Uni Oxford/Diamond), Dr Lori Ferrins, Dr Joe Eyermann (Northeastern University), Dr Jan Jensen (University of Copenhagen), Dr Chris Swain (Cambridge MedChem Consulting), Dr Jan Abendroth, Dr Bart Staker (SSGCID).
  • 15 participants
  • 47 minutes
dose
crystals
preclinical
inhibitors
synthesize
reagents
atpm
research
biochemistry
mirty
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8 Mar 2022
Open project meeting for Open Source Antibiotics Series 1, the Mur Ligases.
Full Project: https://github.com/opensourceantibiotics/murligase
Relevant GitHub Issue: https://github.com/opensourceantibiotics/murligase/issues/70
On the call: Professor Matthew Todd, Dr Edwin Tse, Yuhang Wang, Kato Leonard (UCL), Laura Diaz Saez (University of Warwick), Lizbe Koekemoer (Uni Oxford/Diamond), Dr Lori Ferrins, Dr Joe Eyermann (Northeastern University), Dr Jan Jensen (University of Copenhagen), Dr Chris Swain (Cambridge MedChem Consulting), Dr Jan Abendroth, Dr Bart Staker (SSGCID).
  • 8 participants
  • 56 minutes
inhibitors
dose
becca
consider
enzymology
dmso
screening
laura
epsc
inquiries
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8 Feb 2022
Open project meeting for Open Source Antibiotics Series 1, the Mur Ligases.
Full Project: https://github.com/opensourceantibiotics/murligase
Relevant GitHub Issue: https://github.com/opensourceantibiotics/murligase/issues/66
On the call: Professor Matthew Todd, Dr Edwin Tse, Yuhang Wang, Kato Leonard, Zige Bu, Shah Choudhury (UCL), Professor Chris Dowson, Laura Diaz Saez (University of Warwick), Lizbe Koekemoer, Dr Lori Ferrins, Dr Joe Eyermann (Northeastern University), Dr Jan Jensen (University of Copenhagen), Dr Chris Swain (Cambridge MedChem Consulting), Dr Jan Abendroth, Dr Bart Staker (SSGCID).
  • 16 participants
  • 1:10 hours
introduce
hi
julie
z5595
conversations
dose
present
professor
meet
anybody
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9 Nov 2021
Open project meeting for Open Source Antibiotics Series 1, the Mur Ligases.
Full Project: https://github.com/opensourceantibiotics/murligase
Relevant GitHub Issue: https://github.com/opensourceantibiotics/murligase/issues/57
On the call: Professor Matthew Todd, Dr Dana Klug, Yuhang Wang, Kato Leonard, Zige Bu, Shah Choudhury (UCL), Professor Chris Dowson, Laura Diaz Saez (University of Warwick), Lizbe Koekemoer, Frank von Delft (Diamond/Oxford), Dr Lori Ferrins, Dr Joe Eyermann (Northeastern University), Dr Jan Jensen (University of Copenhagen), Dr Chris Swain (Cambridge MedChem Consulting), Dr Jan Abendroth, Dr Bart Staker (SSGCID).
  • 15 participants
  • 56 minutes
introductions
discussions
hi
meet
consultancy
people
presentation
laura
matt
anybody
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5 Oct 2021
Open project meeting for Open Source Antibiotics Series 1, the Mur Ligases.
Full Project: https://github.com/opensourceantibiotics/murligase
Relevant GitHub Issue: https://github.com/opensourceantibiotics/murligase/issues/51
On the call: Professor Matthew Todd, Dr Dana Klug, Yuhang Wang, Kato Leonard (UCL), Professor Chris Dowson, Laura Diaz Saez (University of Warwick), Lizbe Koekemoer (Diamond/Oxford), Dr Lori Ferrins, Dr Joe Eyermann (NEU), Peter Horanyi (UCB), Dr Jan Jensen (University of Copenhagen).
  • 13 participants
  • 52 minutes
discussed
cysteine
compound
antibiotics
molecular
finally
hypothesis
peter
trouble
having
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6 Jul 2021
Open project meeting for Open Source Antibiotics Series 1, the Mur Ligases.
Full Project: https://github.com/opensourceantibiotics/murligase
Relevant GitHub Issue: https://github.com/opensourceantibiotics/murligase/issues/47
On the call: Professor Matthew Todd, Dr Dana Klug, Yuhang Wang (UCL), Professor Chris Dowson, Laura Diaz Saez, Rebecca Steventon (University of Warwick), Lizbe Koekemoer (Diamond/Oxford), Dr Lori Ferrins, Dr Joe Eyermann (NEU), Peter Horanyi (UCB), Dr Jan Jensen (University of Copenhagen).
  • 10 participants
  • 59 minutes
antibiotics
issue
hopefully
ic50s
prepared
ligand
consensus
taking
reagents
indication
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8 Jun 2021
Open project meeting for Open Source Antibiotics Series 1, the Mur Ligases.
Full Project: https://github.com/opensourceantibiotics/murligase
Relevant GitHub Issue: https://github.com/opensourceantibiotics/murligase/issues/44
On the call: Professor Matthew Todd, Dr Dana Klug, Yuhang Wang (UCL), Professor Chris Dowson, Laura Diaz Saez, Rebecca Steventon (University of Warwick), Lizbe Koekemoer, Gustavo Arruda Bezerra (Diamond/Oxford), Bart Staker (SSGCID), Dr Lori Ferrins, Dr Joe Eyermann (NEU), Peter Horanyi (UCB), Dr Chris Swain (Cambridge MedChem Consulting).
  • 11 participants
  • 40 minutes
synthesis
vials
reaction
inhibitors
chemistry
azad
perizzolo
experiments
finally
crystallize
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11 May 2021
Open project meeting for Open Source Antibiotics Series 1, the Mur Ligases.
Full Project: https://github.com/opensourceantibiotics/murligase
Relevant GitHub Issue: https://github.com/opensourceantibiotics/murligase/issues/43
On the call: Professor Matthew Todd, Dr Dana Klug, Yuhang Wang (UCL), Professor Chris Dowson, Laura Diaz Saez, Rebecca Steventon (University of Warwick), Lizbe Koekemoer, Gustavo Arruda Bezerra (Diamond/Oxford), Bart Staker (SSGCID), Dr Lori Ferrins, Dr Joe Eyermann (NEU), Peter Horanyi (UCB), Dr Chris Swain (Cambridge MedChem Consulting).
  • 11 participants
  • 49 minutes
chemistry
consider
blue
making
experimental
imaging
affinity
reaction
eventually
atomized
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13 Apr 2021
Open project meeting for Open Source Antibiotics Series 1, the Mur Ligases.
Full Project: https://github.com/opensourceantibiotics/murligase
Relevant GitHub Issue: https://github.com/opensourceantibiotics/murligase/issues/42
On the call: Professor Matthew Todd, Dr Dana Klug, Yuhang Wang (UCL), Professor Chris Dowson, Laura Diaz Saez, Rebecca Steventon (University of Warwick), Lizbe Koekemoer (Diamond/Oxford), Bart Staker (SSGCID), Joe Eyermann (NEU), Peter Horanyi (UCB), Dr Chris Swain (Cambridge MedChem Consulting)
  • 11 participants
  • 27 minutes
compounds
assay
nmr
amine
experiments
methyl
chemistry
issue
isocyanate
enema
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9 Mar 2021
Open project meeting for Open Source Antibiotics Series 1, the Mur Ligases.
Full Project: https://github.com/opensourceantibiotics/murligase
Relevant GitHub Issue: https://github.com/opensourceantibiotics/murligase/issues/40
On the call: Professor Matthew Todd, Dr Dana Klug, Yuhang Wang (UCL), Professor Chris Dowson, Laura Diaz Saez (University of Warwick), Lizbe Koekemoer, Gustavo Arrudabezerra (Diamond/Oxford), Bart Staker (SSGCID), Joe Eyermann (NEU), Jan Jensen (University of Copenhagen), Peter Horanyi (UCB).
Partial recording, forgot to switch on, sorry...
  • 8 participants
  • 14 minutes
discussion
thanks
project
approval
laura
having
proposal
issue
joe
provided
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9 Feb 2021
Open project meeting for Open Source Antibiotics Series 1, the Mur Ligases.
Full Project: https://github.com/opensourceantibiotics/murligase
Relevant GitHub Issue: https://github.com/opensourceantibiotics/murligase/issues/39
On the call: Professor Matthew Todd, Dr Dana Klug, Yuhang Wang, Dayang Usop, Giada Sabatino (UCL), Dr Chris Swain (Cambridge MedChem Consulting), Professor Chris Dowson, Becca Steventon, Laura Diaz Saez (University of Warwick), Lizbe Koekemoer, Gustavo Arrudabezerra (Diamond/Oxford), Bart Staker (SSGCID), Joe Eyermann (NEU)
  • 10 participants
  • 27 minutes
crystallize
aza
enamine
developments
batch
chemistry
enzymes
eugene
aez
hopefully
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