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From YouTube: Open Source Antibiotics Science Update Mar 12 2021
Description
Weekly open project meeting for Open Source Antibiotics Series 2.
Full Project: https://github.com/opensourceantibiotics/Series-2-Diarylimidazoles
Relevant GitHub Issue: https://github.com/opensourceantibiotics/Series-2-Diarylimidazoles/issues/59
On the call: Professor Matthew Todd, Dr Dana Klug, Giada Sabatino, Dr Lori Ferrins (Northeastern University), Anthony Sama (citizen scientist).
A
A
B
A
Yes,
I
think
so.
I
think
that
lori
was
offering
some
screening
in
the
dndi
kind
of
pathway
for
toxicity
and
other
things
it
turns
out,
but
one
of
the
reasons
for
doing
that
is
to
sort
of
double
check,
their
toxicity
assay
versus
ours
right
that
was
an
email.
She
we
volunteered
at
last
time
that
she
sent
a
follow-up
email
and
we
said
that
yeah
we'd
probably
send
them
directly
to
her
and
she
can
sort
of
install
them
in
her
essay
and
get
them
screened,
which
would
be
very
good.
A
A
A
Are
these
and
I
was
looking
at
these
last
night?
I
was
thinking
if
these
came
from
that
dndi
project
then
hang
on.
How
do
these
relate
to
the
previous
compounds
that
dndi
sent
us
because
my
my
memory
was
was
weak,
but
I
seem
to
remember
that
those
comments
came
through
and
they
weren't
very
good.
So
I
I
searched
through
them
and
found
them
back
in
issue
35,
and
it
was
these
guys
right
that
were
sent
from
there
and
yeah
they've
got
they've.
So
there
were
some
com.
A
There
were
some
conclusions
from
this,
but
they
were
they're
a
little
bit
tricky.
We
sort
of
found
that
some
of
these
five
member
rings
weren't
working
stuff,
but
the
most
interesting
conclusions
from
these
were
these
guys.
I
think
over
here,
where
we've
got
the
collating
two
period
motif
and
we've
got
a
bunch
of
other
things
going
on
whatever,
but
we've
got
the
nitrogen
and
we've
got
the
pendant
ring
here,
which
is
the
kind
of
thing
that
we
have
in
you
know
the
compounds
that
we
were
just
looking
at
oops.
A
Sorry,
I've
just
lost
the
place
in
them.
You
know
these
guys
here
right.
So
it's
the
same
basic
motif:
we've
got.
You've
got
the
the
the
same
ring
system,
the
two
paradigm
motif
nitrogen
aromatic
ring.
So
I
was
thinking.
Okay,
hang
on
a
minute.
What's
going
on?
What
have
we
learned
here
and
the
thing
we
learned
of
course?
Well,
the
thing
that
this
is
screaming
out
is
that
when
this
is
nh,
it's
no
good
and
when
it's
unalkalated
we
get
potency.
B
C
A
I
guess
I
guess
the
the
thing
I'm
trying
to
emphasize
here
is
that
we
need
to
two.
I
mean
two
things.
One
is
just
to
make
sure
that
we
we
heavily
have
ceremonies,
and
it's
like
the
least
glamorous
thing
of
all
to
do.
You
know
this
nice
tedious
thing
to
aggregate
the
debt
if
we
have
to,
because
I
think
that's
something
something
very
specific
here.
We
have
to
make
sure
the
talks
window
is
there,
so
that's
not
too
excited,
but
certainly
that's
the
most
important
thing
and
the.
D
A
Thing,
though,
is
that
we
need
to
start
writing
up
the.
This
is
the
paper
anyway,
because
we've
got
to
get
something
out,
and
so
it's
not
a
bad
idea
to
start
thinking
about.
Well,
what
are
the
sar
themes
for
a
writer-
and
this
is
a
clear
case
of
something
we've
learned
from
from
screening,
a
bunch
of
companies
which
were
contributed.
A
E
Good
morning
afternoon,
sorry,
I'm
late,
so
I
just
on
on
this
particular
point,
so
I
actually
sent
dana
a
file
this
week
with
a
bunch
of
structures,
so
I
basically
went
through
and
had
a
look
at
anything
and
everything
that
we
have
on
hand
here
at
northeastern
and
look.
We
don't
have
very
many
and
alcohols,
because
that's
something
sort
of
relatively
new
that
we've
been
trying.
E
Having
said
that,
we
have
a
bunch
of
material
that
we
could
potentially
alkylate,
and
so
we're
actually
looking
at
the
moment
to
see
one
which
of
those
actually
makes
sense
in
terms
of
our
sar
like
for
chagas
and
leash.
Do
we
want
to
be
and
alkylating
those
and
then
the
other
part
is
as
well?
I
could
potentially
get
an
undergraduate.
E
A
Okay,
great,
that's,
that's
awesome,
I
mean
yeah,
it
does
depend
on
on
the
talks.
Obviously,
but
I
just
I
guess
you
know,
the
main
learning
as
they
say
from
from
here
is,
is
that
that
is
a
key
motif.
So
there
are
other
things
we
haven't
tinkered
with,
as
we
were
talking
about
last
time.
The
substitution
of
the
pyradine
and-
and
some
of
these
rings
in
theory
could
be
productive
for
us,
because
they've
all
been
tested
here
with
the
free
nh.
A
A
Yeah
these
are,
I
mean
the
yeah
yeah,
okay,
all
right,
so
I
just
wanted
to
emphasize
that
I
mean
in
the
sense
that
you
know
again
with
with
paper
we're
doing
this
with
the
open
source
malaria
paper.
You
know
we're
going
to
be
selecting
out
some
key
things
for
the
for
the
paper
here
and-
and
you
know
these
will
all
appear
in
the
supporting
information.
A
Obviously,
but
but
in
terms
of
our
understanding,
we're
zooming
in
pretty
strongly
on
the
an
alcohol
at
the
moment,
all
right-
so
that's,
I
guess
that's
just
to
you
know
to
flag
up
that
support,
but
that's
that's
great
to
hear
why
thank
you
and
thanks
to
anthony
for
the
for
the
thing
in
the
in
the
chat
winner.
That's
great
all
right!
So
so
these
compounds
are
now
with
alex.
A
I
guess
we'll
we'll
have
to
have
an
update
at
some
point
next
week
about
you
know
what
the
time
scale
is
there,
because
that's
kind
of
a
crucial
experiment.
I
don't
think
alex
is
committed
to
a
time
frame
here
because,
of
course,
he's
busy
with
a
lot
of
other
things,
but
do
you
have
a
sense
of
it?
I
mean
last
time
it
was.
It
was
a
couple
of
weeks
right
at
least.
A
Good
separately
to
that
set
flavio
can't
join
us
posted
some
stuff
last
time
of
of
combat.
So
there's
some
compounds
that
he's
he's
looked
through
in
this
excel
sheet.
That
he's
posted
and
some
other
compounds
that
he
can.
He
can
sort
of
derivatize
fairly
quickly,
based
on
the
project
that
he
was
doing,
and
so
the
thing
that
strikes
me
about
some
of
these
and
it's
great,
he
did
this.
I
think
I've
hang
on.
I'm
gonna
have
to
switch
windows,
wait
a
minute.
A
Zoom
doesn't
perceive
that
I'm
no
longer
looking
in
that
space,
so
the
the
things
he
posted
here
loads
of
data
in
here
really
good.
But
essentially,
I
think
all
of
the
compounds
do
not
possess
the
methyl
chelation
possibility
so
they're,
all
basically
pendant
fennel
rings,
and
so
I'm
not
sure
any
of
these
are
worth
looking
at.
A
To
be
frank,
just
because
we
kind
of
know
that,
when
we're
unlikely
to
get
anything
and
of
the
says
the
first
thing
of
the
other
things,
let
me
just
go
back
to
the
original
screen,
which
I
think
is
that
one
of
the
other
things
here
again.
The
rings
that
he's
thinking
about
functionalizing
don't
offer
much.
Maybe
apart
from
this
guy
down
here,
offer
much
of
a
massive
collision
possibility.
So
I'm
just
not
sure
it's
worth
our
asking
him
for
for
samples
or
further
chemistry
there.
A
A
A
B
So
the
the
first
tab
is
just
a
list
of
all
of
them
and
I
think
it
has
like
the
inchi
key
and
things
like
that
and
then
the
there's
other
tabs
down
at
the
bottom
and
that's
where
the
data
is
so.
The
series
two
tabs
should
have
all
the
talk
data,
any
admin,
data
that
we've
gotten
from
laurier
elsewhere
and
and
everything
and
the
potency
as
well.
A
A
I
mean
without
that
lack
of
weight
for
the
moment,
and
so
all
of
the
things
I
want
to
talk
about
that
was
everything
on
the
mechanism
of
action.
Stuff,
giardia,
you've
been,
you
know,
looking
at
potential
targets,
have
you
got
anything
you
want
to
say
I'm
getting
again
and
put
you
on
the
spot.
You
don't
think
you
want
to
say
about.
You
know
modeling
you're,
looking
at
with
with
molecules
that
look
like
they're
collating,
metals
ions
in
in
the
middle
of
metalloenzymes.