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From YouTube: Open Source Antibiotics Science Update Aug 6th 2021
Description
Weekly open project meeting for Open Source Antibiotics Series 2.
Full Project: https://github.com/opensourceantibiotics/Series-2-Diarylimidazoles
Relevant GitHub Issue: https://github.com/opensourceantibiotics/Series-2-Diarylimidazoles/issues/87
On the call: Professor Matthew Todd, Dr Dana Klug, Dr Edwin Tse, Anthony Sama (Citizen Scientist), Dr Chris Swain (Cambridge Medchem Consulting)
A
A
That
came
through
from
paul,
where
we
we
had
some
interesting
data
back
for
for
mssa,
but
the
the
mercer
results
were
a
little
bit
off
in
the
sense
that
the
control
compound
gave
nothing
so
gave
you
an
activity,
and
so
I
think
that
we're
going
to
have
to
so.
I
asked
paul
if
he
could
redo
that
essay
and
he
said
no
problem.
It's
just
that,
as
with
most
other
people
he's
on
vocation
for
a
bit
so
we'll
get
to
this
at
the
beginning
of
september.
So
we
have
a
bit
of
a
delay
there.
B
A
A
A
Yep,
so
so
we
have
to
wait
unfortunately
and
yeah,
but
anything
comes
in
in
the
meantime
we
can
add
it.
I'm
sure.
I
think
that
there
was
a
I
think.
Paul
mentioned
to
me.
There
was
a
small
change
in
his
in
his
mercer
essay
that
he
recently
bought
in
something-
and
I
forget
what
it
is
sorry
so
there
there
is
a
change
that
that
could
explain
why
the
data
don't
quite
work
for
mersa
in
this
case,
so
he's
very
happy
to
redo
it.
I.
C
A
A
A
A
I
don't
know
what
the
pipeline
is
like
either.
Sorry,
okay
and
then
you
know
alex
is
still
working
on
the
talks
and
I
will
I
will
catch
up
with
her
to
see
how
that
is
going,
because
we
need
that
for
our
paper
and
whatever
in
whatever
form,
and
then
I
was
just
going
to
mention
one
other
thing
briefly,
which
is
oh
the
mechanism.
A
Action
stuff
lee
is
is
on
the
case
and
is,
I
think,
searching
for
the
relevant
compounds
that
we
need
to
run
those
experiments
and
just
correct
if
I'm
wrong,
but
sorry
I'm
just
bringing
it
up
now,
because
there
was
a
comment,
I
think
from
him
about
whether
they
have
enough
compound-
and
he
said
something
like
he's
yeah.
He
hasn't
got
any
comment
left,
but
he
thinks
he
might
be
able
to
get
some
from
some
other
team
member
from
tim
wilson's
group.
A
A
I
I
checked
on
the
grant
status
over
there
and
there's
still
there's
still
money
left
for
him
to
cover
these
experiments,
so
we're
in
good
shape
for
that
all
right
and
then
just
on
the
the
chemistry
so
so
giada.
He
has
those
two
compounds
in
the
the
mercer
evaluation
and
is
finished
in
the
lab.
There
were
some
other
molecules
that
we
could
make
in
theory.
A
A
C
B
A
C
Yeah
one
thing
I
think
that
maybe
we
should
do
is
like
the
match
pair
to
1002,
just
with
the
methyl,
I
I
don't
think
that's
actually
been
tested
and
a
lot
of
our
compounds
kind
of
match.
Back
to
that,
so
I
was
going
to
look
at
making
a
bit
of
that
unless
you
have
some
at
any.
U
I
mean,
I
assume
that
you
guys
would
have
made
that
compound,
but.
C
D
D
A
D
D
D
No,
no
real
answer
is,
is
the
truth
behind
it,
like?
Maybe
you
could
say
that
in
the
actual
whole
cell
itself
there
was
some
metabolism
and
there
was
a
toxic
metabolite
forming
yeah
that
that
isn't
forming
with
the
deutero
compound
by
the
end,
methylation,
but
that's
very
hand
wave,
and
we
have
no
evidence
behind
it.
Yeah.
A
D
B
A
D
A
A
A
Okay,
that
is
interesting
just
to
see
what
we
could
do
with
that,
it's
just
offline
dana.
Would
you
just
mind
talking
to
equivalent
about
the
availability
of
those
materials
and
just
checking
what
we
can
do
with
that?
Is
that
really
handy
and
then
maybe
posting
something
here
about
what
we
can
then
access
by
by
working
with
colon
on
those
molecules?
A
Not
these
sorry
yeah.
I
guess
I
guess
the
I
I
assume
she's
talking
about
these
compounds
here
where
the
idea
was
to
put
on
the
the
alkyl
group,
and
I
think
you
were
saying
that
the
in
order
to
do
that
we'd
need
to
you
guys
would
need
to
resynthesize
some
of
the
core
and
we
would
just
needed
to
discuss
whether
whether
that
was
still
an
aim
is
have
I
got
that
right
or
have
I.
D
D
So
yeah,
so
I'm
I
think
larry
was
just
sort
of
getting
out
with
the
components
of
this
that
were
truly
interesting
to
you
or
is
it
out
of
convenience?
And
if
it's
out
of
convenience
you
assuming
we're
going
to
have
to
resynthesize
some
of
these
if
they're
anything
that
you're
more
interested
that
can
fit
in
with
the
sar
that
you're
of
your
program,
let
us
know
because
it's
it's
just
the
same
amount
of
effort's
going
to
be
put
in.
So
why
not
make
more
impactful
compounds.
B
A
At
this
stage,
the
main
thing
was
to
explore
the
alkylation
of
the
nitrogen,
because
that
was
giving
us
the
most
promising
data.
I
mean
that
was
pretty
much
as
far
as
we
got,
and
so
I
think
the
idea
was
to
try
and
add
on
the
same
group
to
the
nitrogens
here,
whilst
exploring
the
rest
of
the
core
to
see.
If
we
could,
you
know,
combine
potency
associated
with
the
n,
alcohol
and
other
bits
of
the
molecule
and
because
they're
available,
we
thought
well.
A
A
A
A
A
A
All
good,
okay!
Well
great!
I
think
we
will
have
you
know
a
few
weeks
off
and
we
can
discuss
online
and
then
have
first
meeting
back.
I
think
at
the
beginning
of
the
beginning
of
september,
so
I
think
it's
that
september
third
will
be
the
next
one,
if
that's
okay
with
everybody,
so
we
can
communicate
online
as
per
usual.