►
From YouTube: Open Source Antibiotics Science Update Nov 20 2020
Description
Weekly open project meeting for Open Source Antibiotics Series 2.
Full Project: https://github.com/opensourceantibiotics/Series-2-Diarylimidazoles
Relevant GitHub Issue: https://github.com/opensourceantibiotics/Series-2-Diarylimidazoles/issues/41
On the call: Professor Matthew Todd, Dr Dana Klug, Dr Edwin Tse (UCL), Dr Chris Swain (Cambridge MedChem Consulting), Anthony Sama.
B
They
were,
it
wasn't
fun
coalescing
all
those
I
will
say,
yeah.
B
It
was
me
picking
what
I
figured
would
be
interesting
and
what
they
said
they
could
do.
Okay,
I
think
one
of
chris's
compounds
actually
hit
on
the
bottom.
There.
B
A
B
For
them
some
of
the
compounds,
if
you
click
on
the
mql
name,
which
is
hyperlinked
so
let's
say,
click
on
chris's
compound
the
the
one
up,
the
one
up,
one
more
or
the
isopropyl
doesn't
matter.
It
will
give
you
a
rough
idea,
but
they
do
bulk
quotes
so
mql.
I
didn't
contact
them
because.
A
Yeah,
it's
a
it's
a
trade-off.
You
know
it's
interesting
because
by
synthesizing
you
have
more
control
yeah,
but
if,
if
chemistry
is
well
there's
arguments
both
ways
if
chemistry
is
hard
or
too
easy,
there's
a
reason
for
doing
this.
B
I
did
find
something
interesting
from
mql
there.
You
can
put
another
heteroatom
on
the
core
and
it's
very
very
easy
to
do.
It's
literally
just
changing
the
one
with
the
three
nitrogens
in
the
core.
B
You
can
do
very
easily
with
a
compound
called
amino
called
aminopyrazine,
which
is
very
cheap
and
it's
the
same
conditions
as
making
the
original
core
you
just
swap
out
that
thing
for
amino
pyrazine,
and
that
was
that
wasn't
mql
who
said
that
that
was
a
posteris
manifold
which
yeah
this
is
known,
so
you
can
introduce
some
more
cores.
Obviously,
metabolic
stability
is
the
main
issue
now
and
log
p,
of
course,
because
some
of
these
are
pretty
lipophilic.
Some
of
them
aren't
too
bad
and
you
can
actually
export
this
into
a
sdf
file.
A
Yeah
I
mean
it's
something
we
need
to
keep
an
eye
on
right,
I
mean
if
we
we
can
always
supplement
what
we're
doing
in
the
lab
with
molecules
from
here,
particularly
if
we,
you
know,
basically
for
cases
of
molecules
where
we
may
have
to
invest
some
time,
making
a
molecule
that
we
think
is
going
to
be
a
negative
as
part
of
a
control.
Things
like
that,
where
we're
not
hugely
infused
about
making
the
molecules,
it's
a
good
way
of
plugging
some
holes.
A
So
it's
good
that
we
I
mean,
I
guess
dana
and
ed,
just
keep
it
in
mind.
You
know,
as
as
as
a
supplement
to
what
we're
doing
or
if
the
chemistry
is
not
terribly
interesting.
A
I
think
that's
it's
important
all
right,
that's
good
to
know.
Yeah.
B
This
was
just
from
like
one
sleepless
night,
so
it's
not
much
yeah
but
but
I
did
what
I
could
and
that's
what
we've
found
so
far.
A
A
So
the
thanks
for
starting
this
day
now
we
we
can
talk
about
chemistry
in
a
minute,
because
I
think
in
the
in
the
last
meeting
we
had
a
bunch
of
stuff
that
was
summarizing
what
we
are
aiming
for,
so
we
can
catch
up
with
chemistry
in
just
a
second
in
terms
of
the
design,
you
know
what
we're
kind
of
aiming
for
versus
last
time,
I'm
assuming
that
no
one
has
had
any
major
changes
of
heart
about
what
we're
aiming
for
right.
A
A
And
laurie
is
not,
I
don't
think
she's
here,
but
the
she
had
offered
to
send
some
of
those
molecules
from
previously,
and
I
guess
we're
still
in
touch
with
her
about
that.
Are
we
hopefully.
C
A
Okay,
all
right
good
thanks
yeah
I
mean
whatever
she
can
do.
Obviously
is
great
and
oh
yeah.
There
was
an
action
on
youtube
to
reach
out
to
band
about
related.
That
may
have
been
made.
A
That's
fine
just
checking,
okay,
all
good
and
also,
if
you
are
into
july
there
was
this
very
interesting
conversation
last
night
about
what
she
knew
about
toxicology
of
these
things.
So
it
sounds
like
they
have
been
assessing
that
too.
So,
if
we
could
ask
her
for
any
data
that
they're
willing
to
share
on
that,
that'd
be
incredibly
helpful.
C
Yeah,
I
think
they
routinely
get
them
against
a
million
cell
lines,
so
I'll
just
make
sure
that
she
sends
that
to
us.
I
think
she
said
that
that
was
fine.
A
Yeah,
okay
and
I'm
guessing
things
are
still
happening
in
andreas-
is
live
no
updates
right,
no
still
happening.
A
Okay,
all
right
fine,
I
mean,
if,
if
I
mean
we
know
the
two
people
doing
it,
I
mean
in
you
know
early
next
week,
if
you
could
just
ping
them
and
say
how's
it
going
just
it's
a
polite
hassle.
A
D
C
Right
yeah,
so
I've
made
these
cores
with
the
methoxy
and
the
chloro.
I
did
the
suzuki's
this
morning.
They
look
like
they
have
made
products,
so
I
need
to
do
workup
and
purification
on
those,
and
then
I
have
a
enough
of
the
brominated
intermediate
left
to
probably
do
one
more
suzuki
coupling
each
actually,
the
methoxy
have
more
so
I
could
make
more
of
those.
C
A
Just
go
back
to
slide
24,
sorry,
okay,
so
yeah
all
right!
Sorry!
So
so
five
one
seven
one
is
needed
for
that
that
amino
linking
to
the
emitters.
All
right,
that's
the
reason
that's
being
made
right!
So
that's
gonna,
be
our
first
foray
into
that.
C
Parameter
yeah
yeah,
aniline
yeah,
yes,
using
the
18
crown
six
conditions
and
it
didn't
work.
B
Dms
dipy
and
dcm
and
microwave.
B
A
Yeah
die
p
and
dcm,
you
know
forcing
conditions
if
if
it
goes
once
then
then
we're
we're
all
set
right,
because
yeah.
D
Yeah
I
mean
yeah,
so
they
did
these
kind
of
conversions
on
a
lot
of
other
substrates
like
the
benzodiazepine
as
well.
So
it
seems
trustworthy.
B
E
Just
a
sort
of
word
of
caution-
I
guess
really
the
some
of
these
telluridines
and
things
like
this
are
quite
toxic,
so
be
careful
with
them.
E
A
A
A
couple
milligrams-
hopefully
that's
coming
up
on
your
risk
assessments,
guys.
A
Okay,
excellent
so
yeah
I
I
was
looking.
I
finally
got
around
to
looking
at
the
units
thing
they
they
just
it's
interesting
that
so
I
looked
at
the
original
reports.
The
units
are
just
different,
there's
no
reason
for
them
to
be
different.
The
I'll
just
bring
up
what
I
was
looking
at
here.
A
A
I
think
we
can
sort
of
close
the
list,
but
it
was
these
two
numbers
here
for
the
rat,
where
we've
got
the
direct
comparison
between
the
two
and
here
one,
the
monash
number,
which
is
this
one,
should
be
according
to
the
units
in
order
of
magnitude
smaller
than
the
other
one,
because
they're
out
and
there's
no
reason
why
they
should
be
out
it's
the
same
experiment
as
different
units
and,
of
course
it
isn't
out,
but
I
mean
you
know:
we're
always
there's
always
error
in
these
kinds
of
measurements
and
it's
difficult
to
reproduce
them
exactly,
but
but
yeah
we
just
have
to
make
sure
that
you
know
for
the
remaining
units
here
that
we've
got
from
minus.
A
A
A
Okay,
so
I'm
going
to
close
that
and
haifa
and
the
paperwork's
done
we're
good
to
go.
So
I
need
to
forward
an
email
to
you
right
after
this
meeting,
dana
and
ed.
They
want
a
certain
amount
of
compound
in
a
certain
way
and
they
are
going
to
do
a
bunch
of
work
which
I
can
specify
on
on
the
platform
here.
A
So
we
just
finished
the
paperwork
yesterday
and
so
they're
going
to
contribute
they're
going
to
try
and
you
know-
generate
identify,
metabolite
and
they're
going
to
try
to
isolate
the
main
metabolite
so
that
we
can
look
at
what
it
is
and
it's
going
to
be
the
benzo
furan
compound,
which
is
great
all
pro
bono,
which
is
amazing
of
them
and
we're
incredibly
grateful
for
their
work.
And
in
fact
there
is
a.
There
is
a
window
now
where
things
are
reasonably
quiet,
which
wasn't
the
case
a
month
ago.
A
So
I
think
we
can
get
something
done,
which
is
absolutely
awesome.
So
I'll
clarify,
what's
going
to
happen
on
the
website
and
I'll
ping,
you
the
email,
so
we
can
get
that
set
up.
But
if
we
can
ship
that
compound
to
them
asap,
then
the
results
will
come
back
pretty
soon
too.
A
A
Okay,
then
we've
got
this
issue
of
of
multiple
contributions,
so
the
the
sgc
site
that
I
was
referring
to,
where
you
can
request
tools,
is
a
the
idea.
Is
you
read
this
material
and
then
you
fill
in
what
you
want?
A
You
know
what
you're
asking
for
and
you
you
click
a
bunch
of
things
and
you
submit
it
and
then
you
can
get
access
to
those
compounds
because
you
agree
to
the
term.
So
it's
a
quick
wrap
license.
A
If
so,
we
can
definitely
basically
copy
and
copy
and
paste
this
text
if
people
wanted
to
request
compounds
from
us,
but
I
guess
that's
not
really
what
we
were
talking
about
was
it.
We
were
talking
about
people
giving
compounds,
so
I
still
think
I
need
to
modify
this
text
a
little
bit
to
to
talk
about
what
terms
you
want
for
people
who
want
to
donate
compounds,
and
I
just
wanted
to
sort
of
pick
brains
a
little
bit
about
that.
A
So
if,
if
you
were
gonna,
you
know
send
in
a
compound
to
this
effort
and
you
were
happy
for
it
to
be
screened
for
things
like
you
know,
mercer
and
talks.
The
terms
that
you
want
most
likely
would
be.
What
that
I
mean
it's
the
question.
You
know
you,
you
presumably
want
to
know
that
the
data
would
be
taken
on
to
the
project
in
the
same
spirit
so
that
it's
made
for
made
publicly
available.
A
Otherwise,
why
would
you
be
involved?
So
you've
got
to
be
some
sense
about
being
happy
with
with
that,
but
also,
presumably,
we
need
to
clarify
whether
or
not
we
once
we
have
the
sample
are
allowed
to
do
anything
else
with
it,
and
I
would
assume
that
the
answer
to
that
is
no,
that
we're
not
allowed
to
then
send
it
to
somebody
else
for
some
other
purpose
right.
So
it's
not
as
if
it's
by
sending
us
the
molecule
you're,
not
washing
your
hands
of
it,
you're
donating
it
for
this
specific
project.
A
I
mean
one
of
the
issues
with
the
coad
project
talking
to
those
guys
who
had
all
those
compounds
sent
in
and
they
will
have.
You
know
some
terms
also
is
that
nobody
had
agreed
in
advance
about.
You
know
the
shipping
of
those
compounds
for
any
other
purpose,
and
so
it
did
mean
that
down
the
road.
You
know
with
all
those
molecules
in
a
fridge
somewhere
that
nothing
could
be
done
with
those
molecules
beyond
what
was
the
original
idea.
A
Yeah,
well,
I
mean
so,
I
think
it's
if
it's
still
aligned
with
the
project.
I
think
you
would
have
to
give
give
us
the
permission
to
keep
on
investigating
the
molecule
or
or
make
new
versions,
or
you
know,
make
new
batches
of
because
it's
aligned
with
the
project,
but
if,
but
if
it
turns
out
that
the
danger
is,
of
course,
that
if
you
know
if
it
turns
out
the
molecule
looks
like
it
might
be
good
for
something
else
that
we
don't
have
rights
to
progressive.
I
suppose.
E
E
A
Yeah
is
there
I
mean
also
you
want
indemnity
that
you
want
if
it
turns
out
that
the
molecule
is
actually
much
more
toxic
than
you
think,
so
you
send
it
to
us
in
good
faith
without
having
assessed
toxicity
and
it's
later
identified
as
being
a
hazardous
molecule,
you
don't
want
us
going
back
and
suing
them.
So,
presumably
you
want
to
say:
okay,
you
take
the
molecule
as
it
is
even
on
the
understanding
that,
of
course,
it
may
be,
may
have
properties
that
are
unforeseen.
E
E
A
A
It
starts
getting
quite
technical
down
here
when
it
starts
talking
about
making
modifications-
and
I
guess
that
is-
that
is
a
little
bit
relevant,
but
also
also,
I
guess
not
because
we,
if
we're
taking
in
molecule
x
and
we
and
we-
and
it
looks
good
then
if
we
make
x
plus
methyl
that's
nothing
to
do
with
the
submitter,
because
we
have
no
agreement
about
that
molecule
x,
plus
method.
A
I
think
also
there
there's
a
there's
also
needs
to
be
a
term
there
that
we
will.
All
I
mean
we
will
always
credit
contributors,
there'll,
be
an
acknowledgement
of
contribution,
so
it's
not
as
if
you're
going
to
send
the
molecule
in
and
then
you
are
somehow
not
then
linked
with
the
project.
A
A
Okay,
I
need.
I
think
I
need
to
draft
up
some
text
here
for
this
direction.
If
we
ever
give
things
out,
though
I
mean
so
on
twitter,
there's
someone
I
know
in
india
who
wants
to
try
and
screen
some
of
our
molecules,
particularly
the
the
ligase
ones.
A
Actually,
in
this
case,
there's
the
other
project,
one
strand
screen
against
some
tb
motor
ligase
enzymes,
and
so
we
could,
if
we
were
able
to
ship
out,
you
know
90
or
so
molecules
to
that
person,
and
it
would
be
very
useful
if
we
had
something
like
the
text
on
the
screen
for
them
to
say:
okay,
yes,
I
agree
to
your
terms
already
set
up,
but
I
think
that
would
be
less
common
than
us
receiving
things.
A
Okay,
all
good.
That's
still
on
me
to
try
and
clarify
those
two
yeah
all
right.
All
good
mechanism
reaction
is
coming
very
soon.
I
think
they're
just
digesting
the
results
which
is
great
and
there
was
nothing
oh
er.
Did
you
get
a
chance
or
dana?
Did
you
get
a
chance
to
look
at
this
thing
about
molokai
sketching
from
the
library
sketching
facility?
Can
you
search
I've.
A
When
you
get
a
chance
just
see
if
it
works
again,
it
may
take
so
you
know
within
lab
archive.
You
should
be
able
to
find
things
pretty
quickly,
but
then,
if
you
draw
a
molecule
and
with
their
searching
tool-
and
you
put
it
on
the
page-
give
it
a
few
days
to
see
if
the
metadata
goes
to
google,
and
so
you
can
find
it
on
google,
even
without
putting
the
string
in
it's
that
it's
that
thing.
So
we
can
stop
doing
strings
manually.
E
E
E
I'll
keep
checking
it,
but
that
should
be
fine
great.
A
A
E
Okay,
I
mean
I
I've
mentioned
it
to
a
few
people
and
they
said
they'd
be
interested,
but
as
ever
with
these
sort
of
things
that
there
has
to
be
some
kind
of
legal
document,
sure.
A
C
Yeah
so
I
made
the
google
form,
but
two
things
I
was
wondering
is:
if
we
should
put
a
little
bit
of
text
at
the
top
just
saying
like
we
won't
give
your
email
address
to
other
people
and
that
might
make
people
feel
better
about
signing
up
for
it
or
something
I
don't
know,
and
then
probably
we
need
a
way
for
people
to
unsubscribe.
I
don't
know
if
we
have
that
or
not
right
now,
yeah,
but
if
they've
ever
wanted
to
in
the
future.
C
A
All
right
so
there's
a
there's,
a
sorry,
bigger
partner.
Let
me
go
back,
there's
a
there's
a
form,
so
you
go
to
a
page,
there's
a
form
you
fill
it
in
and
then
that
gets
sent
to
a
sheet
somewhere
right.
So
then
we
assemble
a
spreadsheet
of
people.
Who've
agreed
to
be
part
of
the
newsletter
and
then
do
they
do
they
get
a
like
a
confirmation,
email
or
something?
A
A
A
Thanks,
fantastic
yeah,
great,
really,
good,
okay,
I'll,
take
a
look
at
that
and
I
assume
that
the
spreadsheet's
blank
at
the
moment
isn't
it.
E
E
I
was
just
wondering
about
the
you
know,
donated
compounds
and
things
like
that.
How
will
we
handle
if
we
get
the
same
compound
from
two
people.
C
Yeah,
we
can
also
keep
copies
if
they
submit
through
that
excel
sheet
that
I
made
yeah.
We
can
just
keep
copies
of
that.
Maybe
we
just
store
them
on
github,
and
then
that
has
a
place
to
put
institution
that
they
came
from.
A
But
so
when,
if
someone
did
fill
in
the
form
and
and
submit
the
compound,
then
does
that
also
go
to
a
sheet
somewhere.
C
No,
they
would
have
to
email
us
because
it's
excel.
It's
not
google
sheets.
Is
that
what
you?
So?
I
was
just
thinking
that
if
people
had
a
batch,
they
a
batch
of
compounds
they
wanted
to
submit.
You
can
download
that
fill
in
all
the
information
and
then
email
whoever's
receiving
it
and
we
have.
Then
we
have
all
the
details
and
then
you
can
also
email
us.
You
know
the
shipping
information
and
stuff
like
that.
Okay,.
A
A
A
Yeah,
but
the
I
mean
the
advantage
of
the
system
that
you've
got
there
where
you
have
to
go
somewhere
to
fill
it
in.
Is
that
you?
You
can
then
insist
that
people
agree
to
the
license
terms.
That's
the
nice
thing
yeah,
whereas
if
they
just
email
a
sheet
and
then
we
haven't
had
them
agree
to
that,
so
we'd
have
to
have
them
manually,
say
yeah.
I
agree
to
all
those
terms
which
is
possible
because
you
know
at
the
moment
we're
not
going
to
be.
You
know
drowning
in
submitted
compounds.
A
C
Yeah
I'll,
I
can
look
into
that
because
I
think
you
can
do
it.
A
Okay,
that
would
be
neat
because
then
we
could
have
the
terms
right
there,
and
I
don't
know,
I
don't
know
if
you
can
do
like
a
batch
upload
on
google
form.
So
if
you
can
upload
more
than
one
thing
at
a
time
you
know
so
lori's
gonna
send
us
five
or
six
compounds
right.
Did
you
have
to
do
that
five
or
six
times
or
could
you
do
it
in
like
one.
C
Yeah,
so
I
think
what
we
could
do
is
like
set
up
a
full,
a
folder,
and
then
you
can
upload
like
the
excel
sheet
through
the
google
form,
and
they
would
all.
Then
they
would
all
go
to
the
same
place.
C
A
Oh
yeah,
I
I
think
so
yeah
so
I
mean
that's
a
nice
idea
of
like
an
incoming
sheep
for
things
that
are
being
donated.
If
that
can
be
so,
let's
say:
lori
comes
along,
says:
compounds.
Has
it
in
excel?
She
uploads.
It
says
I'm
going
to
submit
these
compounds.
I
agree
to
your
license
terms.
They
appear
in
a
sheet
and
then
someone
looks
and
goes
yeah.
That's
fine!
Here,
I'm
going
to
assign
the
codes
here
then
I'm
going
to
copy
that
over
and
put
it
into
the
main
sheet.
Yeah
yeah.